ProMisMe
Protein misfolding diseases
Protein misfolding diseases (PMDs) are a large group of human disorders caused by the misfolding of specific proteins. These diseases span a wide range of conditions that impact millions of lives, including Alzheimer’s disease, cystic fibrosis, obesity, and retinitis pigmentosa.
Different PMDs are associated with different proteins (soluble or membrane-bound, globular or intrinsically disordered etc.), they affect different organs (brain, lungs, heart, eyes etc.) and they present very distinct pathologies (neurodegeneration, heart failure, blindness etc.). Despite their differences, from the types of proteins involved to the organs they affect and the symptoms they cause, they all share a common molecular thread: protein misfolding.
Different PMDs are associated with different proteins (soluble or membrane-bound, globular or intrinsically disordered etc.), they affect different organs (brain, lungs, heart, eyes etc.) and they present very distinct pathologies (neurodegeneration, heart failure, blindness etc.). Despite their differences, from the types of proteins involved to the organs they affect and the symptoms they cause, they all share a common molecular thread: protein misfolding.
