Our Approach

The primary objective of ProMisMe is to develop engineered yeast (Saccharomyces cerevisiae) that serve as discovery platform for compounds capable of rescuing MisMP misfolding. These compounds are sourced from vast libraries of drug-like molecules biosynthesized within these microbes, leveraging a technology that allows for the rapid production and screening of a vast diversity of test molecules. These libraries are screened in the microbial cells that produce them, and the molecules that effectively rescue MisMP misfolding are selected through ultrahigh-throughput screening.